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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

WTF.2: They Believe You Can Fly
也许同等重要的是,稳定或者下降的油价将会缓解通货膨胀压力使美国工人的工资更具有购买力。Renaissance Macro经济学家Neil Dutta 称“这对于国内需求来说是一个明确的积极的消息,人们将会有更多可以用来消费的钱”。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

2010年中国的计生政策将发生变化吗?
Liu Fei was also a half-brother of the Emperor Wu of Han who ruled from 141BC to 97BC.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Few years in recent decades dawned with as much of a sense of pessimism as 2014. One consistent theme in the predictions for the year was that 2014 looked eerily similar to 1914. Most pundits predicted doom and gloom, especially in east Asia. Yet, while there were many horrific events — from thedowning of flight MH17 over Ukraine, to the abduction of hundreds of schoolgirls in Nigeria and the rise of the Islamic State of Iraq and the Levant — we have avoided outright world war. Now that the year is closed, with no repetition of 1914, it may be wise to investigate why the pundits were wrong, particularly on their ideas around the potential for conflict in Asia.

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 海淀群租房问题半个小时核实完毕
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

其实,中国经济增速放缓至8%左右,对中国乃至世界都是一件好事。更具环境可持续性、更加公平的局面,将缓解社会忧虑,而更高的消费将缓解全球贸易紧张。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 新疆五城市开展住房租赁市场试点
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

其中有铁环的那一个是在江苏西部的仪征市发现的。
联合国世界知识产权组织(WIPO)、英士国际商学院和美国康奈尔大学联合发布的年度报告显示,全球第二大经济体正在赶追创新领域那些传统的领先者。目前,第一集团主要是由瑞士、瑞典、英国和美国引领。
This journey into the mind and feelings of an 11-year-old-girl may be Pixar’s wildest adventure yet. It’s a very funny workplace sitcom (with exuberant, touching performances from Amy Poehler, Phyllis Smith, Mindy Kaling and others), an ingenious allegory of psychological development, and an almost unbearably moving and honest defense of the role of sadness in our lives. (Read the review.)
While the currency exchange limit has not changed, individuals are now required to disclose specific details on how they will use the funds. Funds can only be used towards current account spending such as tourism and shopping, overseas study, foreign medical care and consulting services. Real estate and other investment spending are explicitly forbidden.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Mr. Sissako is both an indispensable political filmmaker and one of the great poets of contemporary cinema. His portrait of life under jihadi rule in northern Mali is brutal and shocking, but also gentle, generous and surprisingly funny. Mr. Sissako does not humanize violent extremists so much as demonstrate that they already belong to the species and reflect part of our common, tragic nature. But his movie also insists that the only effective and ethically serious way to oppose fanaticism is with humanism. Which is to say with irony, with decency and, perhaps above all, with art. (Read the review.)
国家统计局日前在其网站发布了上述数据,称这是科技研发经费增速连续4年下滑后的首次回升。
It is also argued that Friends came about as the family unity of small-town America was being replicated in major urban centers as young people migrated without the maturity or streetsmarts to live alone. Before Friends, sitcoms tended to focus on family dynamics, with parents being the central characters. But when young people strike out on their own in the big city, who do they have for support? They must rely on each other to endure through the overwhelming confusion of youth.
时间:2011-03-08 编辑:beck

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

If the oldest man ever elected president can “tweet like a kindergartner,” why not flip the script and see if a youngster can be elected to office and govern wisely?

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

《秦时丽人明月心》

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

An earlier plan by activists and the US-based Human Rights Foundation to send 100,000 copies of the film in January was postponed until after last month's Lunar New Year.
Most technology developers are seeing app use grow and web use decline. That means companies have to have strong, fast, meaningful mobile platforms and those that don't lose customers.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

单词conservative 联想记忆:
China does not want to see a trade war between the US and China. That would not make our trade fairer and cause loss for the both sides.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Iron ore imports fell 12.3 per cent by volume in October from the previous month and 4.9 per cent from the same month a year earlier while coal imports were down 21.4 per cent from September and 30.7 per cent from a year earlier, according to Chinese customs data.
China had a full-year GDP target of “around 6.5 per cent” for 2017.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

瑞士圣加伦大学(St Gallen)今年继续在英国《金融时报》2016年管理学硕士(MiM)全球排行榜上蝉联冠军。
上榜的15个在线MBA项目为在职高管们提供了灵活的学习选择,他们在毕业时可以获得与全日制“住读”MBA学员一样的学位。
“有个人把一杯咖啡摔在地上后就扬长而去。”
However, you know when your cycles are over when the washer and dryer stop making noise. And you know when the weather is ugly by simply looking outside, or checking your weather app. Therefore, the product is basically just another way hackers can get into your home.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

“暂时没有名字的泡沫”依然是泡沫。但美国人太不在乎、太麻木、太不接受事实,所以听不到警告声音。这让我想起2000年3月20日我一篇文章的标题:“下次崩盘,对不起你们永远不会听到它的到来”(Next crash, sorry you'll never hear it coming)。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 河北将创建600个国家森林乡村
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

今年到目前为止,周星驰的《美人鱼》自二月上旬的贺岁档上映以来,已经取得了5.26亿美元的票房收入。
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

在甲骨文球场以77比111耻辱性地输掉的这场比赛中,科比11投仅1中,其中三分球7投1中,全场只拿下4分。在上个赛季输给圣安东尼奥马刺队的比赛中。他也曾14投1中。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

孙俪在剧中扮演女主周莹。虽然孙俪是1982年生人,但在许多观众眼中,她仍然成功塑造了一个可爱天真的少女周莹。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 规范民宿应多一些“网约”思维
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

['k?mf?t]
Yunge from the Desert
据BusinessInsider.com报道,麦嘉华夸张地说,“QE基本上会成为我们下半辈子日常生活的一部分”。麦嘉华还说,2010年在贝南克灾难性试验的早期阶段,他曾给出“美联储奔向QE99”的警告。
2015年风头最劲的品牌:在新款切诺基的拉动下,Jeep在2014年的销量惊人地拉高了44%,而斯巴鲁的销量则静悄悄地提高了21%,现已成为美国第十大最受欢迎的汽车品牌。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 儿童涂料并非真环保只是营销创意
Review Article

Influenza neuraminidase: A druggable target for natural products

John Hummel, chief investment officer for AIS Group, a fund manager with $400 million under management, said all the new sources of global oil are expensive to extract, and he sees U.S. shale output falling by 2015.
No. The Bank of Japan’s life will get tougher in 2018 as the US Federal Reserve tightens policy and widens the interest rate gap with Japan. But governor Haruhiko Kuroda is determined to hike rates in response to one thing only: inflation. The BoJ may let the yield curve climb a little if prices start to accelerate, but real interest rates in Japan will end 2018 no higher than at the start of the year.
The former Miss Israel, Gal Gadot spot 6th in the list of 10 most beautiful women of 2015. She is the leading fashion model for the clothing company Castro. Gadot is known for her role as Gisele Yashar in The Fast and the Furious film series.
照片左起分别是苹果董事长史蒂夫乔布斯,总裁兼CEO约翰斯卡利,创始人之一的斯蒂夫沃兹尼亚克,他们正在推出新款苹果II c型机,1984年4月24日,旧金山
The University of Pittsburgh team used stem cells made from skin to make MCPs, a special kind of cell that acts as a precursor to cardiovascular tissue. They then placed these cells on a 3-D scaffold designed to support a mouse heart. Within 20 days, the new heart began beating at 40 to 50 beats per minute.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 旧楼装电梯 应引入补偿金制度
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

想要工作稳定,最重要的是你与老板的关系。即使他跟你说:“我很想留住你,但是他们一定要让我辞退你。”这很有可能是假话。他才是那个下决定的人。
中国依然是美国政府债券的最大持有人,10月份中国也减持到1.25万亿美元。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

adj. 最初的,首要的,最好的,典型的

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Miranda Lambert “Bathroom Sink” (RCA Nashville)

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

别让自己工作得太舒服
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.
1997:H5N1传染人类1997: H5N1 Infects Humans
又或者,今年是一群有跟虐待、性或其他有关的故事要讲的女性。她们其中几个人在我们的页面上分享了“我也是”(#MeToo)的经历。卡洛塔·加尔(Carlotta Gall)讲述了汉达·阿亚里(Henda Ayari)的故事。后者是一名拥有北非血统的法国公民,也是一名反萨拉菲派活动人士。她指控牛津大学某知名教授强奸了她。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

这是自从2011年以来谷歌首次荣登榜首。
当很多千禧一代很难找到工作或在低技能岗位上将就时,凭着项目本身与公司合作伙伴的联系以及校友网络,这些管理学硕士项目的毕业生获得了很高的就业率。
unexpectedly
但1998年的记录现已被每四、五年一次的新记录多次打破,而2014年的记录是在没有显著厄尔尼诺现象发生的年度创下的。加文·A·施密特(Gavin A. Schmidt)是位于曼哈顿的美国宇航局戈达德太空研究所的所长,他说,下一次的强厄尔尼诺现象可能会打破所有的温度记录。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

8. Jessica Gomes
包括加拿大在内的北美地区票房收入达到了111亿美元,同比去年上涨8%,这主要要归功于包括《侏罗纪公园》(本土票房6.52亿美元)、《复仇者联盟:奥创纪元》(4.59亿美元)、《头脑特工队》(3.56亿美元)等几部大卖影片。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 顺义300套共有产权房29日申购
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

圣加伦大学校友的薪资排名第三,为114449美元(按购买力平价调整后),排在艾哈迈达巴德的印度管理学院(Indian Institute of Management)和印度管理学院班加罗尔分校(IIM Bangalore)之后,这两所商学院校友的平均薪资分别为116476美元和116094美元。圣加伦大学还在职业服务质量方面排名第一。
阿德瑞娜利玛穿上了红色,亚历山大安布罗休惊艳四座,你能想到她刚生完孩子么?
The second-best song that Shirley Bassey performed for the James Bond franchise is still one of the best. For a series that, on some level, has always been about wish fulfillment, listening to one of the great singers belt powerful notes about avarice seems just about right. So say what you will about the film (it's not on many of the lists of James Bond's best), but Bassey had good material here and she knocked it out of the park.
In news that should come as little surprise to global air travelers, Singapore's done it again.
这封信件在十天以前神奇般的被寄到了加利福尼亚大学的宾夕法尼亚州分校,这所大学位于宾州的东北部。寄给Moore先生的这封信是1958年2月20日的信件,上面还写着“永远爱你的Vonnie”。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 智能风“席卷”名家具展
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

几乎所有的创业者(93%)都将获得新技能列为自己决定读EMBA的重要或非常重要的因素。“我知道自身技能的价值,而不必‘担心’没有工作,”其中一位创业者说。
To put this all in a bit more perspective, the current World Cup is averaging more goals than any of the top leagues around the world averaged in 2013/14. TheNetherlands' Eredivisie was the highest scoring of the top European leagues at 3.20 and the Bundesliga was just a shade behind at 3.16. No other top European league averaged more than 2.80 last season. In theAmericas, Major League Soccer is the current pace setter at 2.89 goals per game.
The thing about the Mavericks is that this is not at all how Dirk should go out. That team has been so solid his entire career. To have a busted season now is painful. Maybe he ought to have joined Kobe, KG, and Big Fundamental last summer.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

intended
But I don't think you can say that to us anymore. Are we even on your list of priorities? My father always says "You are what you do, not what you say." 但我不能再相信这样的话了,孩子们还是你们的优选名单吗?我爸爸总是说:“听其言,观其行,是认识一个人最好的方法”。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
From the themed collection: 前7个月房地产开发投资好于预期
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

其中,国产动作片《战狼2》位居榜首,成了中国史上收入最高的影片,门票销售狂揽56.8亿元。
007系列电影主题曲第二名:蒂娜·特纳--《黄金眼》
根据世界黄金协会的数据,去年中国的黄金产量估计为420.5吨。该组织表示,同期中国对黄金的需求上升了4%,至953.3吨。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

5.重播和比赛精彩集锦同主要现场比赛一样精彩,所以我也会看。
I expect more companies to develop leaders who know how to manage networks — not just the traditional internal network of employees, but more loosely connected webs of suppliers and contractors, managed remotely via the internet and social media.
“现在,我只给她稍微擦了点唇膏,涂了点指甲油。”

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Look up "side-splitting humor" in the dictionary and you should probably come across the trailer for Girls Trip, which is the funniest movie of 2017, no contest.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

在美国许多人居住的大面积地区之中,只有东部在2014年记录到低于平均气温的温度,这与西部的异常高温形成了鲜明对比。有专家认为,造成美国这些极端温度的天气模式是温室气体排放的间接后果,但这个观点尚有待证明。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

FlightAware以航班跟踪应用程序而为旅行者所熟知,从2010年到2012年,这家网站按照美国交通部的规定,统计了感恩节和冬季假期(圣诞节至新年)旅行期间美国18家大航空公司和地区航空公司的航班延误情况。
James Bond Themes Honorable Mention: "Surrender" by K.D. Lang

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 定制家具或将成未来消费热点
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Putin had positive things to say about the Russian economy, saying it has "passed the crisis -- at least, the peak of the crisis."
Paris is in third place with 18.03 million forecast visitors.
北弗罗里达大学的一个有趣的实验证明光脚跑步比穿鞋跑步更能提高记忆力。和那些在实验室和室内坐在桌子边进行的试验不同,在这个实验中,研究人员们引入了一些有趣的观点来探索提高记忆力的奥秘。实验的研究对象为“工作记忆”,即人们加工信息和回顾生活细节的能力。科学家们发现,光脚跑步比起穿鞋跑步来说,可以对记忆力产生轻微的提高。在试验中,年龄为18-44周岁的参与者们被要求跑两轮,一次穿鞋,一次不穿鞋。
He then pressed all the buttons in the hope to get the elevator to work again, but to no avail. Sun then punched the "stop" button, to lock the elevator and secure it won't move.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 老旧小区停车难怎破?
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

4.Virtual Assistant: 17.6 percent increase
去年我国内地人口总数达13.7亿,与2010年进行人口普查时相比,人口数量增加了3377万,这意味着人口年增长率为0.5%。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

The truth is, to shut our door to the outside world would not help China do its own things well, so China will continue to open to the outside world, with this opening-up being a gradual process.
由于州政府和市政府试图打击不法的旅馆经营者,明年可能会出台一项规定。而与此同时,房产租赁网站Airbnb将游说政府改变法规。“你会看到,规范这一市场的要求会变得更加迫切。”代表租户的律师塞缪尔·J·希莫尔斯泰因(Samuel J. Himmelstein)说。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 新疆陶瓷原料列入资源保护
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

在你学习的时候,你要留意会考到的内容,并快速写下实践问题。在笔记本电脑上新建一个文件夹,并将你的问题添加进去。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Others are Ouyeel, a unit of Shanghai Baosteel Group that provides financing for steel traders; and Small Entrepreneur, part of China Merchants Bank — the country’s sixth-largest lender — which focuses on wealth management.
这套邮票价格如此之高的原因是因为这是中华人民共和国1949年建国以来,第一次中国邮政发行的生肖邮票。
1.无论在什么情况下都不要问出租车司机,对于今年夏天伦敦的奥运会有多么激动。不是说他会勉强或尴尬地发表个人意见,而是你根本就不该问这个问题。
While he wins the Nerb prize, the sister prize, for the best verb masquerading as a noun, is won by another consultant who referred to a “global touch-base”.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

There will no longer be any legal obstacle to the implementation of a universal two-child policy, if the draft amendment to the family planning law is approved by the top legislature by Sunday.
Contributing columnist Antoine Gelain is the managing director of Paragon European Partners. He is based in London.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

创业者之间竞争的本质在于效率。好消息是,如今市面上已经有了好几千种优秀的应用软件,能令我们的生活变得更加轻松,但是你不可能有足够的时间把这几千种应用都试上一遍。那么,哪些应用值得你花时间试用一下呢?
At the same time, she said, other countries have seen their tourist numbers spike as the currencies weaken.
2. 在原来工作岗位上呆太久了

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

In fact, create a hard and fast rule to keep work and job searching separate. That means no sneaking out for a phone interview. No browsing job boards. No applying or networking with your work email address. "You don't watch porn at work, and you don't work on your résumé at work," Kay says. "You just don't."
authorization
It adds up to a pointed reminder that Her Royal Swiftness can reclaim her place at pop's cutting edge whenever she feels like it.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

37| “Anomalisa” (Charlie Kaufman/Duke Johnson)|
获奖者:哈里王子殿下

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 房贷利率还会上浮吗?
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

本麦克兰纳汗(Ben McLannahan)是美国银行业编辑
Then in 2011, her mother Melissa was signed up to appeared as part of the Lifetime reality series Dance Moms.
关于英国即将离开欧盟最引人注目的事情是,我们居然仍对脱欧具体会带来什么后果知之甚少。全民公投可是一年多以前的事了。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

国际美容整形外科学会发布的数据显示,若考虑人口因素,韩国现在是全世界整形美容业最大的市场。
The S&P 500’s total return of 14% this year was 40% higher than its 25-year average annual gain. Wall Street’s chief strategists spent much of the last 12 months revising their targets higher from behind. The index printed over 50 all-time record closes, with nearly all investment management professionals racing to at least pull even. A few characteristics made the U.S. stock market particularly difficult to keep up with this year.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

A person walks through snow Tuesday in Belington, West Virginia. Superstorm Sandy buried parts of West Virginia under more than a foot of snow on Tuesday.
Kobe Bryant really hasn't changed that much since high school, even though it's been 16 years since he's walked the halls of Lower Merion High School.
因为一种鲜为人知的病毒所造成的重大影响,2016年将在全球卫生方面被人们铭记。这似曾相识,不过此次登上全球头条新闻的不是埃博拉病毒,而是寨卡——一种通过蚊子传播的病毒,大脑存在缺陷的新生儿数量在巴西急剧增加与此有关。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 北京二手房成交连续3个月破万套
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

约瑟夫?斯蒂格利茨(Joseph Stiglitz)等诺贝尔经济学奖得主、比尔?麦吉本(Bill McKibben)等环保活动人士、乔治?索罗斯(George Soros)及新经济思维研究所(Institute for New Economic Thinking)、阿尔?戈尔(Al Gore)和其他现代思想家全都提醒我们,传统经济学家(以及他们效力的银行、企业和政府机构)都已对坏的经济学理论成瘾,他们在破坏美国的未来。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

这里并不是要给特斯拉浇一瓢冷水。它已经证明自己具有生产一款复杂、先进且外观诱人的产品的能力。但无论是特斯拉自己的内部预测,还是投资人对其股票的追捧,都基于同样一个预期,那就是特斯拉未来依然会延续最近的大热势头。这是一种危险的假设,原因如下:
According to a research report on 2016 graduates released by 51job.com, a leading job hunting platform in China, 52.11% of college graduates found employment or started their own business.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

4.你的同事会泄密。
elegant

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

“The worker threw a brick through the window with the words ‘I quit’ written on it.”
语言本是人们沟通的工具,没有性别之分,但由于男女的社会分工、性格特色、生理特点不同,每一种语言都深深地打上了性别的烙印。在国外,有部分社会语言学家,专门研究语言

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

对于很多西方白人来说,取得“获得性身份认同”(登上山巅)的机会似乎已经变得遥不可及。所以“先赋性身份认同”——也就是他们的“白”——变得比以往更加重要起来。
《人物》评选的电影史上35位美人(1)

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

据《新京报》报道,今年我国高校毕业生达765万人,创历史新高。此外,中职毕业生达435万人,应届毕业生总人数达1200万。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Will the AT&T/Time Warner merger go through without big remedies (such as the sale of CNN)
12. Scientists modify photosynthesis to boost crop yield
创业会对创业者的个人生活造成严重影响。虽然上面的建议对创业成功至关重要,但从精神和身体上照顾好自己同样是必要的。锻炼、睡眠和饮食是确保你成功执行这些策略的关键要素。这些要素能够帮助你调整心态,获得动力,拓展人际关系。
如果计划生育法修正草案在星期日被中国最高立法机关批准,全面二孩政策的实施将不再会有任何法律障碍。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

如果将其切成八片,每片的价值就是250美元,相当于每一口大约值50美元。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

然而据北京出入境边防检查总站(Beijing General Station of Exit and Entry Frontier Inspection)称,只有14,000名旅客办理了过境免签手续,远低于官方此前预计的20,000人。
n. 病毒,病原体
China Everbright, the financial conglomerate that bought the Dah Sing Financial Centre for HK$10bn ($1.29bn), is just one of a number of mainland Chinese companies to have splashed out on headquarters in the city over the past year.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 北京华帝燃具公司财产被查封
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

adj.
201001/93725.shtml

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

“目前市场上有大量尖端,环保的人造皮草,我相信你会同意现在没有任何借口来杀死动物以获取皮草了。”
会。梅亚德是执政党革命制度党(PRI)的候选人。他主要的竞争对手是强硬的左翼领导人安德烈斯曼努埃尔洛佩斯奥夫拉多尔(Andrés Manuel López Obrador)——可以感召人群的激情演说家。梅亚德需要克服很多问题:在去年1月一夜间把油价上调20%、引发通胀飙升后,他必须说服选民自己仍然是可以信任的。他还必须证明自己是个有主见的人,而不仅仅是这届不受欢迎的政府的傀儡——在遏制猖獗的腐败和犯罪行为方面,这届政府极为失败。但是凭借强大的PRI拉票机器,他可能势不可挡。在墨西哥只有一轮选举的体制下,30%的选票可能就足以让他当选总统了。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

法国兴业银行(Societe Generale)国际策略师基特?朱克斯(Kit Juckes)说,过去30年破灭的三个世界级金融大泡沫背后,都是“美联储(Fed)太久时间将政策利率维持在名义经济增长率之下”。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 南京二手房进入买方市场
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

土豆网上有关于这个的记录电影,还有11集中英对照的片子,有兴趣的亲可以找来看看。
彭博(Bloomberg)软性大宗商品指数上涨21%,工业金属和能源指数则分别上涨24%和1.5%。
美国电影学会年度电影奖

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

让自己坐的舒适。在弄了这么多之后,最重要的一点是要让自己感觉到很舒适。
推进健康中国建设。
turkey
(og[coRVqG6sd,

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 买建材,这些陷阱你遇到过吗?
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

地区
反对:可以把这部电影当作一部演技在线的影片,而不是一部真正伟大的作品吗?

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 南京有银行首套房贷利率上浮25%
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

More than 90 per cent of alumni from the most recent graduating classes accepted a job offer within three months of completing their programme.
“现在关注‘星二代’、‘富二代’的比较多,但是‘农民工二代’更需要人们关注。”
单词slew 联想记忆:

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

●"Pope Francis Shocks World, Endorses Donald Trump for President, Releases Statement"
China must walk a narrow line at a time when its outgoing leadership is reluctant to take any far-sighted decisions.

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